                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> COMPOSITIONS AND METHODS FOR MODULATING HYDROXYLATION OF ACC2 BY 
      PHD3

<130> HMV-246.25

<140> PCT/US2016/026461
<141> 2016-04-07

<150> 62/144,165
<151> 2015-04-07

<160> 73    

<170> PatentIn version 3.5

<210> 1
<211> 239
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


<210> 2
<211> 2458
<212> PRT
<213> Homo sapiens

<400> 2
Met Val Leu Leu Leu Cys Leu Ser Cys Leu Ile Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Ile 
            20                  25                  30          


Thr Lys Ser Lys Ser Glu Ala Asn Leu Ile Pro Ser Gln Glu Pro Phe 
        35                  40                  45              


Pro Ala Ser Asp Asn Ser Gly Glu Thr Pro Gln Arg Asn Gly Glu Gly 
    50                  55                  60                  


His Thr Leu Pro Lys Thr Pro Ser Gln Ala Glu Pro Ala Ser His Lys 
65                  70                  75                  80  


Gly Pro Lys Asp Ala Gly Arg Arg Arg Asn Ser Leu Pro Pro Ser His 
                85                  90                  95      


Gln Lys Pro Pro Arg Asn Pro Leu Ser Ser Ser Asp Ala Ala Pro Ser 
            100                 105                 110         


Pro Glu Leu Gln Ala Asn Gly Thr Gly Thr Gln Gly Leu Glu Ala Thr 
        115                 120                 125             


Asp Thr Asn Gly Leu Ser Ser Ser Ala Arg Pro Gln Gly Gln Gln Ala 
    130                 135                 140                 


Gly Ser Pro Ser Lys Glu Asp Lys Lys Gln Ala Asn Ile Lys Arg Gln 
145                 150                 155                 160 


Leu Met Thr Asn Phe Ile Leu Gly Ser Phe Asp Asp Tyr Ser Ser Asp 
                165                 170                 175     


Glu Asp Ser Val Ala Gly Ser Ser Arg Glu Ser Thr Arg Lys Gly Ser 
            180                 185                 190         


Arg Ala Ser Leu Gly Ala Leu Ser Leu Glu Ala Tyr Leu Thr Thr Gly 
        195                 200                 205             


Glu Ala Glu Thr Arg Val Pro Thr Met Arg Pro Ser Met Ser Gly Leu 
    210                 215                 220                 


His Leu Val Lys Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg 
225                 230                 235                 240 


Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly 
                245                 250                 255     


Asp Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala Ala 
            260                 265                 270         


Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg 
        275                 280                 285             


Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu 
    290                 295                 300                 


Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro Val 
305                 310                 315                 320 


Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Val 
                325                 330                 335     


Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly 
            340                 345                 350         


His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys Asn Gly 
        355                 360                 365             


Val Ala Phe Leu Gly Pro Pro Ser Glu Ala Met Trp Ala Leu Gly Asp 
    370                 375                 380                 


Lys Ile Ala Ser Thr Val Val Ala Gln Thr Leu Gln Val Pro Thr Leu 
385                 390                 395                 400 


Pro Trp Ser Gly Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Asp Leu 
                405                 410                 415     


Gln Gln Gly Lys Arg Ile Ser Val Pro Glu Asp Val Tyr Asp Lys Gly 
            420                 425                 430         


Cys Val Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly 
        435                 440                 445             


Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile 
    450                 455                 460                 


Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro Ile Leu Phe Arg Gln Val 
465                 470                 475                 480 


Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln 
                485                 490                 495     


His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly Asn 
            500                 505                 510         


Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
        515                 520                 525             


Lys Ile Val Glu Glu Ala Pro Ala Thr Ile Ala Pro Leu Ala Ile Phe 
    530                 535                 540                 


Glu Phe Met Glu Gln Cys Ala Ile Arg Leu Ala Lys Thr Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser Phe 
                565                 570                 575     


His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr 
            580                 585                 590         


Glu Met Ile Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala 
        595                 600                 605             


Met Gly Val Pro Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly 
    610                 615                 620                 


Glu Ser Pro Trp Gly Val Thr Pro Ile Ser Phe Glu Thr Pro Ser Asn 
625                 630                 635                 640 


Pro Pro Leu Ala Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu 
                645                 650                 655     


Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu 
            660                 665                 670         


Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala 
        675                 680                 685             


Thr Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys Phe 
    690                 695                 700                 


Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val Ala 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr 
                725                 730                 735     


Leu Ile Asn Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Asp Ile Asp 
            740                 745                 750         


Thr Gly Trp Leu Asp Tyr Leu Ile Ala Glu Lys Val Gln Ala Glu Lys 
        755                 760                 765             


Pro Asp Ile Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala Asp 
    770                 775                 780                 


Ala Met Phe Arg Thr Cys Met Thr Asp Phe Leu His Ser Leu Glu Arg 
785                 790                 795                 800 


Gly Gln Val Leu Pro Ala Asp Ser Leu Leu Asn Leu Val Asp Val Glu 
                805                 810                 815     


Leu Ile Tyr Gly Gly Val Lys Tyr Ile Leu Lys Val Ala Arg Gln Ser 
            820                 825                 830         


Leu Thr Met Phe Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp 
        835                 840                 845             


Ala His Arg Leu Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Asn 
    850                 855                 860                 


Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr 
865                 870                 875                 880 


Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val 
                885                 890                 895     


Leu Arg Ser Pro Ser Ala Gly Lys Leu Thr Gln Tyr Thr Val Glu Asp 
            900                 905                 910         


Gly Gly His Val Glu Ala Gly Ser Ser Tyr Ala Glu Met Glu Val Met 
        915                 920                 925             


Lys Met Ile Met Thr Leu Asn Val Gln Glu Arg Gly Arg Val Lys Tyr 
    930                 935                 940                 


Ile Lys Arg Pro Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Arg 
945                 950                 955                 960 


Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu Pro Phe Thr 
                965                 970                 975     


Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Lys Leu 
            980                 985                 990         


His Gln Val Phe His Ser Val Leu  Glu Asn Leu Thr Asn  Val Met Ser 
        995                 1000                 1005             


Gly Phe  Cys Leu Pro Glu Pro  Val Phe Ser Ile Lys  Leu Lys Glu 
    1010                 1015                 1020             


Trp Val  Gln Lys Leu Met Met  Thr Leu Arg His Pro  Ser Leu Pro 
    1025                 1030                 1035             


Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser Val Ala  Gly Arg Ile 
    1040                 1045                 1050             


Pro Ala  Pro Val Glu Lys Ser  Val Arg Arg Val Met  Ala Gln Tyr 
    1055                 1060                 1065             


Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln Phe Pro  Ser Gln Gln 
    1070                 1075                 1080             


Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala Thr Leu  Gln Arg Lys 
    1085                 1090                 1095             


Ala Asp  Arg Glu Val Phe Phe  Ile Asn Thr Gln Ser  Ile Val Gln 
    1100                 1105                 1110             


Leu Val  Gln Arg Tyr Arg Ser  Gly Ile Arg Gly Tyr  Met Lys Thr 
    1115                 1120                 1125             


Val Val  Leu Asp Leu Leu Arg  Arg Tyr Leu Arg Val  Glu His His 
    1130                 1135                 1140             


Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val Ile Asn  Leu Arg Glu 
    1145                 1150                 1155             


Gln Phe  Lys Pro Asp Met Ser  Gln Val Leu Asp Cys  Ile Phe Ser 
    1160                 1165                 1170             


His Ala  Gln Val Ala Lys Lys  Asn Gln Leu Val Ile  Met Leu Ile 
    1175                 1180                 1185             


Asp Glu  Leu Cys Gly Pro Asp  Pro Ser Leu Ser Asp  Glu Leu Ile 
    1190                 1195                 1200             


Ser Ile  Leu Asn Glu Leu Thr  Gln Leu Ser Lys Ser  Glu His Cys 
    1205                 1210                 1215             


Lys Val  Ala Leu Arg Ala Arg  Gln Ile Leu Ile Ala  Ser His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val Glu Ser  Ile Phe Leu 
    1235                 1240                 1245             


Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe Cys Pro  Glu Asn Leu 
    1250                 1255                 1260             


Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile Phe Asp  Val Leu Pro 
    1265                 1270                 1275             


Thr Phe  Phe Tyr His Ala Asn  Lys Val Val Cys Met  Ala Ser Leu 
    1280                 1285                 1290             


Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala Tyr Glu  Leu Asn Ser 
    1295                 1300                 1305             


Leu Gln  His Arg Gln Leu Pro  Asp Gly Thr Cys Val  Val Glu Phe 
    1310                 1315                 1320             


Gln Phe  Met Leu Pro Ser Ser  His Pro Asn Arg Met  Thr Val Pro 
    1325                 1330                 1335             


Ile Ser  Ile Thr Asn Pro Asp  Leu Leu Arg His Ser  Thr Glu Leu 
    1340                 1345                 1350             


Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys Gln Arg  Met Gly Ala 
    1355                 1360                 1365             


Met Val  Ala Phe Arg Arg Phe  Glu Asp Phe Thr Arg  Asn Phe Asp 
    1370                 1375                 1380             


Glu Val  Ile Ser Cys Phe Ala  Asn Val Pro Lys Asp  Thr Pro Leu 
    1385                 1390                 1395             


Phe Ser  Glu Ala Arg Thr Ser  Leu Tyr Ser Glu Asp  Asp Cys Lys 
    1400                 1405                 1410             


Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu Asn Val  Ser Ile Gln 
    1415                 1420                 1425             


Cys Ala  Asp His Leu Glu Asp  Glu Ala Leu Val Pro  Ile Leu Arg 
    1430                 1435                 1440             


Thr Phe  Val Gln Ser Lys Lys  Asn Ile Leu Val Asp  Tyr Gly Leu 
    1445                 1450                 1455             


Arg Arg  Ile Thr Phe Leu Ile  Ala Gln Glu Lys Glu  Phe Pro Lys 
    1460                 1465                 1470             


Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe Ala Glu  Asp Arg Ile 
    1475                 1480                 1485             


Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Asn 
    1490                 1495                 1500             


Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val Pro Cys  Ala Asn His 
    1505                 1510                 1515             


Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys Val Lys  Glu Gly Val 
    1520                 1525                 1530             


Glu Val  Thr Asp His Arg Phe  Phe Ile Arg Ala Ile  Ile Arg His 
    1535                 1540                 1545             


Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe Glu Tyr  Leu Gln Asn 
    1550                 1555                 1560             


Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met Asp Glu  Leu Glu Val 
    1565                 1570                 1575             


Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp Cys Asn  His Ile Phe 
    1580                 1585                 1590             


Leu Asn  Phe Val Pro Thr Val  Ile Met Asp Pro Phe  Lys Ile Glu 
    1595                 1600                 1605             


Glu Ser  Val Arg Tyr Met Val  Met Arg Tyr Gly Ser  Arg Leu Trp 
    1610                 1615                 1620             


Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys Ile Asn  Ile Arg Gln 
    1625                 1630                 1635             


Thr Thr  Thr Gly Ser Ala Val  Pro Ile Arg Leu Phe  Ile Thr Asn 
    1640                 1645                 1650             


Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu Tyr Lys  Glu Val Thr 
    1655                 1660                 1665             


Asp Ser  Arg Ser Gly Asn Ile  Met Phe His Ser Phe  Gly Asn Lys 
    1670                 1675                 1680             


Gln Gly  Pro Gln His Gly Met  Leu Ile Asn Thr Pro  Tyr Val Thr 
    1685                 1690                 1695             


Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln Ala Gln  Thr Leu Gly 
    1700                 1705                 1710             


Thr Thr  Tyr Ile Tyr Asp Phe  Pro Glu Met Phe Arg  Gln Ala Leu 
    1715                 1720                 1725             


Phe Lys  Leu Trp Gly Ser Pro  Asp Lys Tyr Pro Lys  Asp Ile Leu 
    1730                 1735                 1740             


Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln Gly Gln  Leu Val Glu 
    1745                 1750                 1755             


Met Asn  Arg Leu Pro Gly Gly  Asn Glu Val Gly Met  Val Ala Phe 
    1760                 1765                 1770             


Lys Met  Arg Phe Lys Thr Gln  Glu Tyr Pro Glu Gly  Arg Asp Val 
    1775                 1780                 1785             


Ile Val  Ile Gly Asn Asp Ile  Thr Phe Arg Ile Gly  Ser Phe Gly 
    1790                 1795                 1800             


Pro Gly  Glu Asp Leu Leu Tyr  Leu Arg Ala Ser Glu  Met Ala Arg 
    1805                 1810                 1815             


Ala Glu  Gly Ile Pro Lys Ile  Tyr Val Ala Ala Asn  Ser Gly Ala 
    1820                 1825                 1830             


Arg Ile  Gly Met Ala Glu Glu  Ile Lys His Met Phe  His Val Ala 
    1835                 1840                 1845             


Trp Val  Asp Pro Glu Asp Pro  His Lys Gly Phe Lys  Tyr Leu Tyr 
    1850                 1855                 1860             


Leu Thr  Pro Gln Asp Tyr Thr  Arg Ile Ser Ser Leu  Asn Ser Val 
    1865                 1870                 1875             


His Cys  Lys His Ile Glu Glu  Gly Gly Glu Ser Arg  Tyr Met Ile 
    1880                 1885                 1890             


Thr Asp  Ile Ile Gly Lys Asp  Asp Gly Leu Gly Val  Glu Asn Leu 
    1895                 1900                 1905             


Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ser Ser Leu  Ala Tyr Glu 
    1910                 1915                 1920             


Glu Ile  Val Thr Ile Ser Leu  Val Thr Cys Arg Ala  Ile Gly Ile 
    1925                 1930                 1935             


Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg Val Ile  Gln Val Glu 
    1940                 1945                 1950             


Asn Ser  His Ile Ile Leu Thr  Gly Ala Ser Ala Leu  Asn Lys Val 
    1955                 1960                 1965             


Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn Gln Leu  Gly Gly Val 
    1970                 1975                 1980             


Gln Ile  Met His Tyr Asn Gly  Val Ser His Ile Thr  Val Pro Asp 
    1985                 1990                 1995             


Asp Phe  Glu Gly Val Tyr Thr  Ile Leu Glu Trp Leu  Ser Tyr Met 
    2000                 2005                 2010             


Pro Lys  Asp Asn His Ser Pro  Val Pro Ile Ile Thr  Pro Thr Asp 
    2015                 2020                 2025             


Pro Ile  Asp Arg Glu Ile Glu  Phe Leu Pro Ser Arg  Ala Pro Tyr 
    2030                 2035                 2040             


Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro His Pro  Thr Leu Lys 
    2045                 2050                 2055             


Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His Gly Ser  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Ala Pro Trp Ala Gln  Thr Val Val Thr Gly  Arg Ala Arg 
    2075                 2080                 2085             


Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala Val Glu  Thr Arg Thr 
    2090                 2095                 2100             


Val Glu  Val Ala Val Pro Ala  Asp Pro Ala Asn Leu  Asp Ser Glu 
    2105                 2110                 2115             


Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val Trp Phe  Pro Asp Ser 
    2120                 2125                 2130             


Ala Tyr  Lys Thr Ala Gln Ala  Val Lys Asp Phe Asn  Arg Glu Lys 
    2135                 2140                 2145             


Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg Gly Phe  Ser Gly Gly 
    2150                 2155                 2160             


Met Lys  Asp Met Tyr Asp Gln  Val Leu Lys Phe Gly  Ala Tyr Ile 
    2165                 2170                 2175             


Val Asp  Gly Leu Arg Gln Tyr  Lys Gln Pro Ile Leu  Ile Tyr Ile 
    2180                 2185                 2190             


Pro Pro  Tyr Ala Glu Leu Arg  Gly Gly Ser Trp Val  Val Ile Asp 
    2195                 2200                 2205             


Ala Thr  Ile Asn Pro Leu Cys  Ile Glu Met Tyr Ala  Asp Lys Glu 
    2210                 2215                 2220             


Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly Thr Val  Glu Ile Lys 
    2225                 2230                 2235             


Phe Arg  Lys Lys Asp Leu Ile  Lys Ser Met Arg Arg  Ile Asp Pro 
    2240                 2245                 2250             


Ala Tyr  Lys Lys Leu Met Glu  Gln Leu Gly Glu Pro  Asp Leu Ser 
    2255                 2260                 2265             


Asp Lys  Asp Arg Lys Asp Leu  Glu Gly Arg Leu Lys  Ala Arg Glu 
    2270                 2275                 2280             


Asp Leu  Leu Leu Pro Ile Tyr  His Gln Val Ala Val  Gln Phe Ala 
    2285                 2290                 2295             


Asp Phe  His Asp Thr Pro Gly  Arg Met Leu Glu Lys  Gly Val Ile 
    2300                 2305                 2310             


Ser Asp  Ile Leu Glu Trp Lys  Thr Ala Arg Thr Phe  Leu Tyr Trp 
    2315                 2320                 2325             


Arg Leu  Arg Arg Leu Leu Leu  Glu Asp Gln Val Lys  Gln Glu Ile 
    2330                 2335                 2340             


Leu Gln  Ala Ser Gly Glu Leu  Ser His Val His Ile  Gln Ser Met 
    2345                 2350                 2355             


Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly Ala Val  Lys Ala Tyr 
    2360                 2365                 2370             


Leu Trp  Asp Asn Asn Gln Val  Val Val Gln Trp Leu  Glu Gln His 
    2375                 2380                 2385             


Trp Gln  Ala Gly Asp Gly Pro  Arg Ser Thr Ile Arg  Glu Asn Ile 
    2390                 2395                 2400             


Thr Tyr  Leu Lys His Asp Ser  Val Leu Lys Thr Ile  Arg Gly Leu 
    2405                 2410                 2415             


Val Glu  Glu Asn Pro Glu Val  Ala Val Asp Cys Val  Ile Tyr Leu 
    2420                 2425                 2430             


Ser Gln  His Ile Ser Pro Ala  Glu Arg Ala Gln Val  Val His Leu 
    2435                 2440                 2445             


Leu Ser  Thr Met Asp Ser Pro  Ala Ser Thr 
    2450                 2455             


<210> 3
<211> 2448
<212> PRT
<213> Mus sp.

<400> 3
Met Val Leu Leu Leu Phe Leu Thr Cys Leu Val Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Leu 
            20                  25                  30          


Thr Asn Ser Lys Val Glu Ala Asn Leu Leu Ser Ser Glu Glu Ser Leu 
        35                  40                  45              


Ser Ala Ser Glu Leu Ser Gly Glu Gln Leu Gln Glu His Gly Asp His 
    50                  55                  60                  


Ser Cys Leu Ser Tyr Arg Gly Pro Arg Asp Ala Ser Gln Gln Arg Asn 
65                  70                  75                  80  


Ser Leu Pro Ser Ser Cys Gln Arg Pro Pro Arg Asn Pro Leu Ser Ser 
                85                  90                  95      


Asn Asp Thr Trp Pro Ser Pro Glu Leu Gln Thr Asn Trp Thr Ala Ala 
            100                 105                 110         


Pro Gly Pro Glu Val Pro Asp Ala Asn Gly Leu Ser Phe Pro Ala Arg 
        115                 120                 125             


Pro Pro Ser Gln Arg Thr Val Ser Pro Ser Arg Glu Asp Arg Lys Gln 
    130                 135                 140                 


Ala His Ile Lys Arg Gln Leu Met Thr Ser Phe Ile Leu Gly Ser Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Ser Asp Glu Asp Pro Ser Ala Gly Ser Phe Gln Asn 
                165                 170                 175     


Ser Ser Arg Lys Ser Ser Arg Ala Ser Leu Gly Thr Leu Ser Gln Glu 
            180                 185                 190         


Ala Ala Leu Asn Thr Ser Asp Pro Glu Ser His Ala Pro Thr Met Arg 
        195                 200                 205             


Pro Ser Met Ser Gly Leu His Leu Val Lys Arg Gly Arg Glu His Lys 
    210                 215                 220                 


Lys Leu Asp Leu His Arg Asp Phe Thr Val Ala Ser Pro Ala Glu Phe 
225                 230                 235                 240 


Val Thr Arg Phe Gly Gly Asn Arg Val Ile Glu Lys Val Leu Ile Ala 
                245                 250                 255     


Asn Asn Gly Ile Ala Ala Val Lys Cys Met Arg Ser Ile Arg Arg Trp 
            260                 265                 270         


Ala Tyr Glu Met Phe Arg Asn Glu Arg Ala Ile Arg Phe Val Val Met 
        275                 280                 285             


Val Thr Pro Glu Asp Leu Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala 
    290                 295                 300                 


Asp Gln Tyr Val Pro Val Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala 
305                 310                 315                 320 


Asn Val Glu Leu Ile Ile Asp Ile Ala Lys Arg Ile Pro Val Gln Ala 
                325                 330                 335     


Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Lys Leu Pro Glu 
            340                 345                 350         


Leu Leu Cys Lys His Glu Ile Ala Phe Leu Gly Pro Pro Ser Glu Ala 
        355                 360                 365             


Met Trp Ala Leu Gly Asp Lys Ile Ala Ser Thr Ile Val Ala Gln Thr 
    370                 375                 380                 


Leu Gln Ile Pro Thr Leu Pro Trp Ser Gly Ser Gly Leu Thr Val Glu 
385                 390                 395                 400 


Trp Thr Glu Asp Ser Arg His Gln Gly Lys Cys Ile Ser Val Pro Glu 
                405                 410                 415     


Asp Val Tyr Glu Gln Gly Cys Val Lys Asp Val Asp Glu Gly Leu Gln 
            420                 425                 430         


Ala Ala Glu Lys Ile Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly 
        435                 440                 445             


Gly Gly Gly Lys Gly Ile Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro 
    450                 455                 460                 


Met Leu Phe Arg Gln Val Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe 
465                 470                 475                 480 


Leu Met Lys Leu Ala Gln Asn Ala Arg His Leu Glu Val Gln Val Leu 
                485                 490                 495     


Ala Asp Gln Tyr Gly Asn Ala Val Ser Leu Phe Gly Arg Asp Cys Ser 
            500                 505                 510         


Ile Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Thr Ile 
        515                 520                 525             


Ala Ala Pro Ala Val Phe Glu Phe Met Glu Gln Cys Ala Val Leu Leu 
    530                 535                 540                 


Ala Lys Met Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr 
545                 550                 555                 560 


Ser Gln Asp Gly Ser Phe His Phe Leu Glu Leu Asn Pro Arg Leu Gln 
                565                 570                 575     


Val Glu His Pro Cys Thr Glu Met Ile Ala Asp Val Asn Leu Pro Ala 
            580                 585                 590         


Ala Gln Leu Gln Ile Ala Met Gly Val Pro Leu His Arg Leu Lys Asp 
        595                 600                 605             


Ile Arg Leu Leu Tyr Gly Glu Ser Pro Trp Gly Val Thr Pro Ile Pro 
    610                 615                 620                 


Phe Glu Thr Pro Leu Ser Pro Pro Ile Ala Arg Gly His Val Ile Ala 
625                 630                 635                 640 


Ala Arg Ile Thr Ser Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser 
                645                 650                 655     


Gly Thr Val Gln Glu Leu Asn Phe Arg Ser Asn Lys Asn Val Trp Gly 
            660                 665                 670         


Tyr Phe Ser Val Ala Ala Ala Gly Gly Leu His Glu Phe Ala Asp Ser 
        675                 680                 685             


Gln Phe Gly His Cys Phe Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile 
    690                 695                 700                 


Ser Asn Met Val Val Ala Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe 
705                 710                 715                 720 


Arg Thr Thr Val Glu Tyr Leu Val Asn Leu Leu Glu Thr Glu Ser Phe 
                725                 730                 735     


Gln Asn Asn Asp Ile Asp Thr Gly Trp Leu Asp His Leu Ile Ala Gln 
            740                 745                 750         


Arg Val Gln Ala Glu Lys Pro Asp Ile Met Leu Gly Val Val Cys Gly 
        755                 760                 765             


Ala Leu Asn Val Ala Asp Ala Met Phe Arg Thr Cys Met Thr Glu Phe 
    770                 775                 780                 


Leu His Ser Leu Glu Arg Gly Gln Val Leu Pro Ala Asp Ser Leu Leu 
785                 790                 795                 800 


Asn Ile Val Asp Val Glu Leu Ile Tyr Gly Gly Ile Lys Tyr Ala Leu 
                805                 810                 815     


Lys Val Ala Arg Gln Ser Leu Thr Met Phe Val Leu Ile Met Asn Gly 
            820                 825                 830         


Cys His Ile Glu Ile Asp Ala His Arg Leu Asn Asp Gly Gly Leu Leu 
        835                 840                 845             


Leu Ser Tyr Asn Gly Ser Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val 
    850                 855                 860                 


Asp Ser Tyr Arg Ile Thr Ile Gly Asn Lys Thr Cys Val Phe Glu Lys 
865                 870                 875                 880 


Glu Asn Asp Pro Thr Val Leu Arg Ser Pro Ser Ala Gly Lys Leu Met 
                885                 890                 895     


Gln Tyr Thr Val Glu Asp Gly Asp His Val Glu Ala Gly Ser Ser Tyr 
            900                 905                 910         


Ala Glu Met Glu Val Met Lys Met Ile Met Thr Leu Asn Val Gln Glu 
        915                 920                 925             


Ser Gly Arg Val Lys Tyr Ile Lys Arg Pro Gly Val Ile Leu Glu Ala 
    930                 935                 940                 


Gly Cys Val Val Ala Arg Leu Glu Leu Asp Asp Pro Ser Lys Val His 
945                 950                 955                 960 


Ala Ala Gln Pro Phe Thr Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro 
                965                 970                 975     


Ile Leu Gly Glu Lys Leu His Gln Val Phe His Gly Val Leu Glu Asn 
            980                 985                 990         


Leu Thr Asn Val Met Ser Gly Tyr  Cys Leu Pro Glu Pro  Phe Phe Ser 
        995                 1000                 1005             


Met Lys  Leu Lys Asp Trp Val  Gln Lys Leu Met Met  Thr Leu Arg 
    1010                 1015                 1020             


His Pro  Ser Leu Pro Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser 
    1025                 1030                 1035             


Val Ala  Gly Arg Ile Pro Ala  Pro Val Glu Lys Ala  Val Arg Arg 
    1040                 1045                 1050             


Val Met  Ala Gln Tyr Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln 
    1055                 1060                 1065             


Phe Pro  Ser Gln Gln Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala 
    1070                 1075                 1080             


Thr Leu  Gln Arg Lys Ala Asp  Arg Glu Val Phe Phe  Met Asn Thr 
    1085                 1090                 1095             


Gln Ser  Ile Val Gln Leu Val  Gln Arg Tyr Arg Ser  Gly Thr Arg 
    1100                 1105                 1110             


Gly Tyr  Met Lys Ala Val Val  Leu Asp Leu Leu Arg  Lys Tyr Leu 
    1115                 1120                 1125             


Asn Val  Glu His His Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val 
    1130                 1135                 1140             


Ile Asn  Leu Arg Glu Gln Phe  Lys Pro Asp Met Thr  Gln Val Leu 
    1145                 1150                 1155             


Asp Cys  Ile Phe Ser His Ser  Gln Val Ala Lys Lys  Asn Gln Leu 
    1160                 1165                 1170             


Val Thr  Met Leu Ile Asp Glu  Leu Cys Gly Pro Asp  Pro Thr Leu 
    1175                 1180                 1185             


Ser Asp  Glu Leu Thr Ser Ile  Leu Cys Glu Leu Thr  Gln Leu Ser 
    1190                 1195                 1200             


Arg Ser  Glu His Cys Lys Val  Ala Leu Arg Ala Arg  Gln Val Leu 
    1205                 1210                 1215             


Ile Ala  Ser His Leu Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val 
    1220                 1225                 1230             


Glu Ser  Ile Phe Leu Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe 
    1235                 1240                 1245             


Cys Pro  Glu Asn Leu Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile 
    1250                 1255                 1260             


Phe Asp  Val Leu Pro Thr Phe  Phe Tyr His Glu Asn  Lys Val Val 
    1265                 1270                 1275             


Cys Met  Ala Ser Leu Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala 
    1280                 1285                 1290             


Tyr Glu  Leu Asn Ser Leu Gln  His Arg Glu Leu Pro  Asp Gly Thr 
    1295                 1300                 1305             


Cys Val  Val Glu Phe Gln Phe  Met Leu Pro Ser Ser  His Pro Asn 
    1310                 1315                 1320             


Arg Met  Ala Val Pro Ile Ser  Val Ser Asn Pro Asp  Leu Leu Arg 
    1325                 1330                 1335             


His Ser  Thr Glu Leu Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys 
    1340                 1345                 1350             


Gln Arg  Met Gly Ala Met Val  Ala Phe Arg Arg Phe  Glu Glu Phe 
    1355                 1360                 1365             


Thr Arg  Asn Phe Asp Glu Val  Ile Ser Cys Phe Ala  Asn Val Gln 
    1370                 1375                 1380             


Thr Asp  Thr Leu Leu Phe Ser  Lys Ala Cys Thr Ser  Leu Tyr Ser 
    1385                 1390                 1395             


Glu Glu  Asp Ser Lys Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu 
    1400                 1405                 1410             


Asn Val  Ala Ile Gln Cys Ala  Asp His Met Glu Asp  Glu Ala Leu 
    1415                 1420                 1425             


Val Pro  Val Phe Arg Ala Phe  Val Gln Ser Lys Lys  His Ile Leu 
    1430                 1435                 1440             


Val Asp  Tyr Gly Leu Arg Arg  Ile Thr Phe Leu Val  Ala Gln Glu 
    1445                 1450                 1455             


Arg Glu  Phe Pro Lys Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe 
    1460                 1465                 1470             


Ala Glu  Asp Arg Ile Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe 
    1475                 1480                 1485             


Gln Leu  Glu Leu Ser Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val 
    1490                 1495                 1500             


Pro Cys  Ala Asn His Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys 
    1505                 1510                 1515             


Val Lys  Glu Gly Leu Glu Val  Thr Asp His Arg Phe  Phe Ile Arg 
    1520                 1525                 1530             


Ala Ile  Ile Arg His Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe 
    1535                 1540                 1545             


Glu Tyr  Leu Gln Asn Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met 
    1550                 1555                 1560             


Asp Glu  Leu Glu Val Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp 
    1565                 1570                 1575             


Cys Asn  His Ile Phe Leu Asn  Phe Val Pro Thr Val  Ile Met Asp 
    1580                 1585                 1590             


Pro Leu  Lys Ile Glu Glu Ser  Val Arg Asp Met Val  Met Arg Tyr 
    1595                 1600                 1605             


Gly Ser  Arg Leu Trp Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys 
    1610                 1615                 1620             


Ile Asn  Ile Arg Gln Thr Thr  Ser Asp Ser Ala Ile  Pro Ile Arg 
    1625                 1630                 1635             


Leu Phe  Ile Thr Asn Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu 
    1640                 1645                 1650             


Tyr Arg  Glu Val Thr Asp Ser  Arg Ser Gly Asn Ile  Met Phe His 
    1655                 1660                 1665             


Ser Phe  Gly Asn Lys Gln Gly  Ser Leu His Gly Met  Leu Ile Asn 
    1670                 1675                 1680             


Thr Pro  Tyr Val Thr Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln 
    1685                 1690                 1695             


Ala Gln  Ser Leu Gly Thr Thr  Tyr Val Tyr Asp Phe  Pro Glu Met 
    1700                 1705                 1710             


Phe Arg  Gln Ala Leu Phe Lys  Leu Trp Gly Ser Pro  Glu Lys Tyr 
    1715                 1720                 1725             


Pro Lys  Asp Ile Leu Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln 
    1730                 1735                 1740             


Gly Gln  Leu Val Glu Met Asn  Arg Leu Pro Gly Cys  Asn Glu Val 
    1745                 1750                 1755             


Gly Met  Val Ala Phe Lys Met  Arg Phe Lys Thr Pro  Glu Tyr Pro 
    1760                 1765                 1770             


Glu Gly  Arg Asp Ala Val Val  Ile Gly Asn Asp Ile  Thr Phe Gln 
    1775                 1780                 1785             


Ile Gly  Ser Phe Gly Ile Gly  Glu Asp Phe Leu Tyr  Leu Arg Ala 
    1790                 1795                 1800             


Ser Glu  Met Ala Arg Thr Glu  Gly Ile Pro Gln Ile  Tyr Leu Ala 
    1805                 1810                 1815             


Ala Asn  Ser Gly Ala Arg Met  Gly Leu Ala Glu Glu  Ile Lys Gln 
    1820                 1825                 1830             


Ile Phe  Gln Val Ala Trp Val  Asp Pro Glu Asp Pro  His Lys Gly 
    1835                 1840                 1845             


Phe Arg  Tyr Leu Tyr Leu Thr  Pro Gln Asp Tyr Thr  Gln Ile Ser 
    1850                 1855                 1860             


Ser Gln  Asn Ser Val His Cys  Lys His Ile Glu Asp  Glu Gly Glu 
    1865                 1870                 1875             


Ser Arg  Tyr Val Ile Val Asp  Val Ile Gly Lys Asp  Ala Asn Leu 
    1880                 1885                 1890             


Gly Val  Glu Asn Leu Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ala 
    1895                 1900                 1905             


Ser Leu  Ala Tyr Glu Lys Thr  Val Thr Ile Ser Met  Val Thr Cys 
    1910                 1915                 1920             


Arg Ala  Leu Gly Ile Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg 
    1925                 1930                 1935             


Val Ile  Gln Val Glu Asn Ser  His Ile Ile Leu Thr  Gly Ala Gly 
    1940                 1945                 1950             


Ala Leu  Asn Lys Val Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn 
    1955                 1960                 1965             


Gln Leu  Gly Gly Val Gln Ile  Met His Thr Asn Gly  Val Ser His 
    1970                 1975                 1980             


Val Thr  Val Pro Asp Asp Phe  Glu Gly Val Cys Thr  Ile Leu Glu 
    1985                 1990                 1995             


Trp Leu  Ser Phe Ile Pro Lys  Asp Asn Arg Ser Pro  Val Pro Ile 
    2000                 2005                 2010             


Thr Thr  Pro Ser Asp Pro Ile  Asp Arg Glu Ile Glu  Phe Thr Pro 
    2015                 2020                 2025             


Thr Lys  Ala Pro Tyr Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro 
    2030                 2035                 2040             


His Pro  Thr Leu Lys Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His 
    2045                 2050                 2055             


Gly Ser  Phe Lys Glu Ile Met  Ala Pro Trp Ala Gln  Thr Val Val 
    2060                 2065                 2070             


Thr Gly  Arg Ala Arg Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala 
    2075                 2080                 2085             


Val Glu  Thr Arg Thr Val Glu  Val Ala Val Pro Ala  Asp Pro Ala 
    2090                 2095                 2100             


Asn Leu  Asp Ser Glu Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val 
    2105                 2110                 2115             


Trp Phe  Pro Asp Ser Ala Tyr  Lys Thr Ala Gln Val  Ile Arg Asp 
    2120                 2125                 2130             


Phe Asn  Lys Glu Arg Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg 
    2135                 2140                 2145             


Gly Phe  Ser Gly Gly Met Lys  Asp Met Tyr Glu Gln  Met Leu Lys 
    2150                 2155                 2160             


Phe Gly  Ala Tyr Ile Val Asp  Gly Leu Arg Leu Tyr  Glu Gln Pro 
    2165                 2170                 2175             


Ile Leu  Ile Tyr Ile Pro Pro  Cys Ala Glu Leu Arg  Gly Gly Ser 
    2180                 2185                 2190             


Trp Val  Val Leu Asp Ser Thr  Ile Asn Pro Leu Cys  Ile Glu Met 
    2195                 2200                 2205             


Tyr Ala  Asp Lys Glu Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly 
    2210                 2215                 2220             


Thr Val  Glu Ile Lys Phe Arg  Lys Lys Asp Leu Val  Lys Thr Ile 
    2225                 2230                 2235             


Arg Arg  Ile Asp Pro Val Cys  Lys Lys Leu Val Gly  Gln Leu Gly 
    2240                 2245                 2250             


Lys Ala  Gln Leu Pro Asp Lys  Asp Arg Lys Glu Leu  Glu Gly Gln 
    2255                 2260                 2265             


Leu Lys  Ala Arg Glu Glu Leu  Leu Leu Pro Ile Tyr  His Gln Val 
    2270                 2275                 2280             


Ala Val  Gln Phe Ala Asp Leu  His Asp Thr Pro Gly  His Met Leu 
    2285                 2290                 2295             


Glu Lys  Gly Ile Ile Ser Asp  Val Leu Glu Trp Lys  Thr Ala Arg 
    2300                 2305                 2310             


Thr Phe  Phe Tyr Trp Arg Leu  Arg Arg Leu Leu Leu  Glu Ala Gln 
    2315                 2320                 2325             


Val Lys  Gln Glu Ile Leu Arg  Ala Ser Pro Glu Leu  Asn His Glu 
    2330                 2335                 2340             


His Thr  Gln Ser Met Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly 
    2345                 2350                 2355             


Ala Val  Lys Ala Tyr Leu Trp  Asp Ser Asn Gln Val  Val Val Gln 
    2360                 2365                 2370             


Trp Leu  Glu Gln His Trp Ser  Ala Lys Asp Gly Leu  Arg Ser Thr 
    2375                 2380                 2385             


Ile Arg  Glu Asn Ile Asn Tyr  Leu Lys Arg Asp Ser  Val Leu Lys 
    2390                 2395                 2400             


Thr Ile  Gln Ser Leu Val Gln  Glu His Pro Glu Val  Ile Met Asp 
    2405                 2410                 2415             


Cys Val  Ala Tyr Leu Ser Gln  His Leu Thr Pro Ala  Glu Arg Ile 
    2420                 2425                 2430             


Gln Val  Ala Gln Leu Leu Ser  Thr Thr Glu Ser Pro  Ala Ser Ser 
    2435                 2440                 2445             


<210> 4
<211> 2456
<212> PRT
<213> Rattus sp.

<400> 4
Met Val Leu Leu Leu Phe Leu Thr Tyr Leu Val Phe Ser Cys Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Arg Pro Leu 
            20                  25                  30          


Ser Asn Ser Lys Val Asp Ala Ser Leu Leu Pro Ser Lys Glu Glu Ser 
        35                  40                  45              


Phe Ala Ser Asp Gln Ser Glu Glu His Gly Asp Cys Ser Cys Pro Leu 
    50                  55                  60                  


Thr Thr Pro Asp Gln Glu Glu Leu Ala Ser His Gly Gly Pro Val Asp 
65                  70                  75                  80  


Ala Ser Gln Gln Arg Asn Ser Val Pro Thr Ser His Gln Lys Pro Pro 
                85                  90                  95      


Arg Asn Pro Leu Ser Ser Asn Asp Thr Cys Ser Ser Pro Glu Leu Gln 
            100                 105                 110         


Thr Asn Gly Val Ala Ala Pro Gly Ser Glu Val Pro Glu Ala Asn Gly 
        115                 120                 125             


Leu Pro Phe Pro Ala Arg Pro Gln Thr Gln Arg Thr Gly Ser Pro Thr 
    130                 135                 140                 


Arg Glu Asp Lys Lys Gln Ala Pro Ile Lys Arg Gln Leu Met Thr Ser 
145                 150                 155                 160 


Phe Ile Leu Gly Ser Leu Asp Asp Asn Ser Ser Asp Glu Asp Pro Ser 
                165                 170                 175     


Ser Asn Ser Phe Gln Thr Ser Ser Arg Lys Gly Ser Arg Asp Ser Leu 
            180                 185                 190         


Gly Thr Cys Ser Gln Glu Ala Ala Leu Asn Thr Ala Asp Pro Glu Ser 
        195                 200                 205             


His Thr Pro Thr Met Arg Pro Ser Met Ser Gly Leu His Leu Val Lys 
    210                 215                 220                 


Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg Asp Phe Thr Val 
225                 230                 235                 240 


Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly Asn Arg Val Ile 
                245                 250                 255     


Glu Thr Val Leu Ile Ala Asn Asn Gly Ile Ala Ala Val Lys Trp Met 
            260                 265                 270         


Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg Asn Glu Arg Ala 
        275                 280                 285             


Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu Lys Ala Asn Ala 
    290                 295                 300                 


Glu Tyr Tyr Lys Met Ala Asp Pro Val Leu Pro Val Pro Gly Gly Pro 
305                 310                 315                 320 


Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Ile Asp Ile Ala Lys 
                325                 330                 335     


Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu 
            340                 345                 350         


Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys His Gly Ile Ala Phe Leu 
        355                 360                 365             


Gly Pro Arg Val Arg Pro Met Leu Gly Leu Gly Asp Arg Leu Ser Ser 
    370                 375                 380                 


Thr Ile Val Ala Gln Thr Leu Gln Ile Pro Thr Leu Pro Trp Ser Gly 
385                 390                 395                 400 


Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Ser Gln His Gln Gly Lys 
                405                 410                 415     


Cys Ile Ser Val Thr Glu Asp Val Tyr Glu Gln Gly Cys Val Arg Asp 
            420                 425                 430         


Val Asp Glu Gly Leu Gln Ala Ala Glu Lys Val Gly Phe Pro Leu Met 
        435                 440                 445             


Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile Arg Gln Ala Glu 
    450                 455                 460                 


Ser Ala Glu Asp Phe Pro Cys Phe Phe Arg Gln Val Gln Ser Glu Ile 
465                 470                 475                 480 


Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln Asn Ala Arg His 
                485                 490                 495     


Leu Glu Val Gln Val Leu Ala Asp Gln Tyr Gly Asn Ala Val Ser Leu 
            500                 505                 510         


Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln Lys Ile Ile Glu 
        515                 520                 525             


Glu Ala Pro Ala Asn Ile Ala Ala Pro Ala Val Phe Glu Phe Met Glu 
    530                 535                 540                 


Gln Cys Ala Val Leu Leu Ala Lys Thr Val Val Tyr Val Ser Ala Gly 
545                 550                 555                 560 


Thr Val Gly Tyr Leu Tyr Ser Gln Asp Gly Ser Phe His Phe Leu Glu 
                565                 570                 575     


Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr Glu Met Ile Ala 
            580                 585                 590         


Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala Met Gly Val Pro 
        595                 600                 605             


Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly Glu Ser Pro Trp 
    610                 615                 620                 


Gly Val Thr Pro Val Ser Phe Glu Thr Pro Leu Ser Pro Pro Ile Ala 
625                 630                 635                 640 


Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu Asn Pro Asp Glu 
                645                 650                 655     


Ala Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu Asn Phe Arg Ser 
            660                 665                 670         


Asn Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala Ala Gly Gly Leu 
        675                 680                 685             


His Glu Phe Pro Ile Ser Gln Phe Gly His Cys Phe Ser Trp Gly Glu 
    690                 695                 700                 


Asn Gln Glu Glu Ala Ile Ser Asn Met Val Val Ala Leu Lys Glu Leu 
705                 710                 715                 720 


Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr Leu Val Asn Leu 
                725                 730                 735     


Leu Glu Thr Glu Ser Leu Gln Asn Asn Asp Ile Asp Thr Gly Trp Leu 
            740                 745                 750         


Asp His Leu Ile Ala Gln Arg Val Gln Ala Glu Lys Pro Asp Ile Met 
        755                 760                 765             


Leu Gly Val Val Phe Gly Ala Leu Asn Val Ala Asp Ala Met Phe Arg 
    770                 775                 780                 


Thr Cys Ile Thr Glu Phe Leu His Ser Leu Glu Arg Gly Gln Val Leu 
785                 790                 795                 800 


Pro Ala Asp Ser Leu Leu Asn Ile Val Asp Val Glu Leu Ile Tyr Gly 
                805                 810                 815     


Gly Ile Lys Tyr Val Leu Lys Val Ala Arg Gln Ser Leu Thr Met Phe 
            820                 825                 830         


Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp Ala His Arg Pro 
        835                 840                 845             


Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Ser Ser Tyr Thr Thr 
    850                 855                 860                 


Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr Ile Gly Asn Lys 
865                 870                 875                 880 


Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val Leu Arg Ser Pro 
                885                 890                 895     


Ser Ala Gly Lys Leu Met Gln Tyr Thr Val Glu Asp Gly Gln His Val 
            900                 905                 910         


Glu Val Gly Ser Ser Tyr Ala Glu Met Glu Val Met Lys Met Ile Met 
        915                 920                 925             


Thr Leu Asn Val Gln Glu Ser Gly Arg Val Asn Tyr Ile Lys Arg Pro 
    930                 935                 940                 


Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Lys Leu Glu Leu Asp 
945                 950                 955                 960 


Asp Pro Ser Lys Val His Ala Ala Gln Pro Phe Thr Gly Glu Leu Pro 
                965                 970                 975     


Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Arg Leu His Gln Val Phe 
            980                 985                 990         


His Ser Val Leu Glu Asn Leu Thr  Asn Val Met Asn Gly  Tyr Cys Leu 
        995                 1000                 1005             


Pro Glu  Pro Phe Phe Ser Met  Lys Leu Lys Asp Trp  Val Glu Lys 
    1010                 1015                 1020             


Pro Met  Met Thr Leu Arg His  Pro Ser Leu Pro Leu  Leu Glu Leu 
    1025                 1030                 1035             


Gln Glu  Ile Met Thr Ser Val  Ala Asp Arg Ile Pro  Val Pro Val 
    1040                 1045                 1050             


Glu Lys  Ala Val Arg Arg Val  Phe Ala Gln Asp Ala  Ser Asn Ile 
    1055                 1060                 1065             


Thr Ser  Val Leu Cys Gln Phe  Pro Ser Gln Gln Ile  Ala Thr Ile 
    1070                 1075                 1080             


Leu Asp  Cys His Ala Ala Thr  Leu Gln Arg Lys Val  Asp Arg Glu 
    1085                 1090                 1095             


Ala Phe  Phe Met Asn Thr Gln  Ser Ile Val Gln Leu  Ile Gln Arg 
    1100                 1105                 1110             


Tyr Arg  Ser Gly Thr Arg Gly  Ile Met Lys Ala Val  Val Leu Asp 
    1115                 1120                 1125             


Leu Leu  Arg Arg Tyr Leu Asn  Val Glu His His Phe  Gln Gln Ala 
    1130                 1135                 1140             


His Tyr  Asp Lys Cys Val Ile  Asn Leu Arg Glu Gln  Phe Lys Ala 
    1145                 1150                 1155             


Asp Met  Thr Arg Val Leu Asp  Cys Ile Phe Ser His  Ser Gln Val 
    1160                 1165                 1170             


Ala Lys  Lys Asn Gln Leu Val  Thr Met Leu Ile Asp  Glu Leu Cys 
    1175                 1180                 1185             


Gly Pro  Asp Pro Thr Leu Ser  Glu Glu Leu Thr Ser  Ile Leu Lys 
    1190                 1195                 1200             


Glu Leu  Thr Gln Leu Ser Arg  Ser Glu His Cys Lys  Val Ala Leu 
    1205                 1210                 1215             


Arg Ala  Arg Gln Val Leu Ile  Ala Ser His Leu Pro  Ser Tyr Glu 
    1220                 1225                 1230             


Leu Arg  His Asn Gln Val Glu  Ser Ser Ser Cys Gln  Pro Leu Thr 
    1235                 1240                 1245             


Cys Asn  Gly His Gln Phe Cys  Pro Glu Asn Leu Lys  Lys Leu Ile 
    1250                 1255                 1260             


Leu Ser  Glu Thr Thr Ile Phe  Asp Val Leu Pro Thr  Phe Phe Tyr 
    1265                 1270                 1275             


His Ala  Asn Lys Val Val Cys  Met Ala Ser Leu Glu  Val Tyr Val 
    1280                 1285                 1290             


Arg Arg  Gly Tyr Ile Ala Tyr  Glu Leu Asn Ser Leu  Gln His Arg 
    1295                 1300                 1305             


Glu Leu  Pro Asp Gly Thr Cys  Val Val Glu Phe Gln  Phe Met Leu 
    1310                 1315                 1320             


Pro Ser  Ser His Pro Asn Arg  Met Ala Met Pro Ile  Asn Val Ser 
    1325                 1330                 1335             


Asp Pro  Asp Leu Leu Arg His  Ser Lys Glu Leu Phe  Met Asp Ser 
    1340                 1345                 1350             


Gly Phe  Ser Pro Leu Cys His  Gln Arg Met Gly Ala  Met Val Ala 
    1355                 1360                 1365             


Phe Arg  Arg Phe Glu Glu Phe  Thr Arg Asn Phe Asp  Glu Val Ile 
    1370                 1375                 1380             


Ser Cys  Phe Ala Asn Val Pro  Thr Asp Thr Pro Leu  Phe Ser Lys 
    1385                 1390                 1395             


Ala Cys  Thr Ser Leu Tyr Ser  Glu Glu Asp Ser Lys  Ser Leu Gln 
    1400                 1405                 1410             


Glu Glu  Pro Ile His Ile Leu  Asn Val Ala Ile Gln  Cys Ala Asp 
    1415                 1420                 1425             


His Met  Glu Asp Glu Arg Leu  Val Pro Val Phe Arg  Ala Phe Val 
    1430                 1435                 1440             


Gln Ser  Lys Lys His Ile Leu  Val Asp Tyr Gly Leu  Arg Arg Ile 
    1445                 1450                 1455             


Thr Phe  Leu Ile Ala Gln Glu  Lys Glu Phe Pro Lys  Phe Phe Thr 
    1460                 1465                 1470             


Phe Arg  Ala Arg Asp Glu Phe  Ala Glu Asp Arg Ile  Tyr Arg His 
    1475                 1480                 1485             


Leu Glu  Pro Gly Leu Ala Phe  Gln Leu Glu Leu Ser  Arg Met Arg 
    1490                 1495                 1500             


Asn Phe  Asp Leu Thr Ala Val  Pro Cys Ala Asn His  Lys Met His 
    1505                 1510                 1515             


Leu Tyr  Leu Gly Ala Ala Lys  Val Lys Glu Gly Leu  Glu Val Thr 
    1520                 1525                 1530             


Asp His  Arg Phe Phe Ile Arg  Ala Ile Ile Arg His  Ser Asp Leu 
    1535                 1540                 1545             


Ile Thr  Lys Glu Ala Ser Phe  Glu Tyr Leu Gln Asn  Glu Gly Glu 
    1550                 1555                 1560             


Arg Leu  Leu Leu Glu Ala Met  Asp Glu Leu Glu Val  Ala Phe Asn 
    1565                 1570                 1575             


Asn Thr  Ser Val Arg Thr Asp  Cys Asn His Ile Phe  Leu Asn Phe 
    1580                 1585                 1590             


Val Ala  His Val Ile Met Asp  Pro Leu Lys Ile Glu  Glu Ser Val 
    1595                 1600                 1605             


Arg Ala  Met Val Met Arg Tyr  Gly Ser Arg Leu Trp  Lys Leu Arg 
    1610                 1615                 1620             


Val Leu  Gln Ala Gln Val Lys  Ile Asn Ile Arg Gln  Thr Thr Ser 
    1625                 1630                 1635             


Asp Cys  Ala Val Pro Ile Arg  Leu Phe Ile Thr Asn  Glu Ser Gly 
    1640                 1645                 1650             


Tyr Tyr  Leu Asp Ile Ser Leu  Tyr Lys Glu Val Thr  Asp Ser Arg 
    1655                 1660                 1665             


Ser Gly  Asn Ile Met Phe His  Ser Phe Gly Asn Lys  Gln Gly Ser 
    1670                 1675                 1680             


Leu His  Gly Met Leu Ile Asn  Thr Pro Tyr Val Thr  Lys Asp Leu 
    1685                 1690                 1695             


Leu Gln  Ala Lys Arg Phe Gln  Ala Gln Ser Leu Gly  Thr Thr Tyr 
    1700                 1705                 1710             


Val Tyr  Asp Phe Pro Glu Met  Phe Arg Gln Ala Leu  Phe Lys Leu 
    1715                 1720                 1725             


Trp Gly  Ser Pro Glu Lys Tyr  Gly Pro Asp Ile Leu  Thr Tyr Thr 
    1730                 1735                 1740             


Glu Leu  Val Leu Asp Ser Gln  Gly Gln Leu Val Glu  Met Asn Arg 
    1745                 1750                 1755             


Leu Pro  Gly Cys Asn Glu Val  Gly Met Val Val Phe  Lys Met Arg 
    1760                 1765                 1770             


Phe Lys  Thr Pro Glu Tyr Pro  Glu Gly Arg Asp Thr  Ile Val Ile 
    1775                 1780                 1785             


Gly Asn  Asp Ile Thr Phe Gln  Ile Gly Ser Phe Gly  Ile Gly Glu 
    1790                 1795                 1800             


Asp Phe  Leu Tyr Leu Arg Ala  Ser Glu Met Ala Arg  Thr Glu Gly 
    1805                 1810                 1815             


Ile Pro  Gln Ile Tyr Leu Ala  Ala Asn Ser Gly Ala  Val Leu Gly 
    1820                 1825                 1830             


Leu Ser  Glu Glu Ile Lys Gln  Ile Phe Gln Val Ala  Trp Val Asp 
    1835                 1840                 1845             


Pro Glu  Asp Pro Tyr Lys Gly  Phe Arg Tyr Leu Tyr  Leu Tyr Leu 
    1850                 1855                 1860             


Thr Pro  Gln Asp Tyr Thr Gln  Ile Ser Ser Gln Asn  Ser Val His 
    1865                 1870                 1875             


Cys Lys  His Ile Glu Asp Glu  Gly Glu Ser Gly Ile  Ile Val Asp 
    1880                 1885                 1890             


Val Ile  Gly Lys Asp Ser Ser  Leu Gly Val Glu Asn  Leu Arg Gly 
    1895                 1900                 1905             


Ser Gly  Met Ile Ala Gly Glu  Ala Ser Leu Ala Tyr  Glu Lys Asn 
    1910                 1915                 1920             


Val Thr  Ile Ser Met Val Asp  Cys Arg Ala Ile Gly  Ile Gly Ala 
    1925                 1930                 1935             


Tyr Leu  Val Arg Leu Gly Gln  Arg Val Ile Gln Val  Glu Asn Ser 
    1940                 1945                 1950             


His Ile  Ile Leu Thr Gly Ala  Gly Ala Leu Asn Lys  Val Leu Gly 
    1955                 1960                 1965             


Arg Glu  Val Tyr Thr Ser Asn  Asn Gln Leu Gly Gly  Val Gln Ile 
    1970                 1975                 1980             


Met His  Thr Asn Gly Val Ser  His Val Thr Val Pro  Asp Asp Phe 
    1985                 1990                 1995             


Glu Gly  Val Cys Thr Ile Leu  Glu Trp Leu Ser Tyr  Ile Pro Lys 
    2000                 2005                 2010             


Asp Asn  Gln Ser Pro Val Pro  Ile Ile Thr Pro Ser  Asp Pro Ile 
    2015                 2020                 2025             


Asp Arg  Glu Ile Glu Phe Thr  Pro Thr Lys Ala Pro  Tyr Asp Pro 
    2030                 2035                 2040             


Arg Trp  Leu Leu Ala Gly Arg  Pro His Pro Thr Leu  Lys Gly Thr 
    2045                 2050                 2055             


Trp Gln  Ser Gly Phe Phe Asp  His Gly Ser Phe Lys  Glu Ile Met 
    2060                 2065                 2070             


Ala Pro  Trp Asp Gln Thr Val  Val Thr Gly Arg Ala  Arg Leu Gly 
    2075                 2080                 2085             


Gly Ile  Pro Val Gly Val Ile  Ala Val Glu Thr Arg  Ser Val Glu 
    2090                 2095                 2100             


Val Ala  Val Pro Ala His Pro  Ala Asn Leu Asp Ser  Glu Ala Lys 
    2105                 2110                 2115             


Ile Ile  Gln Gln Ala Gly Gln  Val Trp Phe Pro Asp  Ser Ala Phe 
    2120                 2125                 2130             


Lys Thr  Ala Gln Val Ile Arg  Asp Phe Asn Gln Glu  His Leu Leu 
    2135                 2140                 2145             


Leu Met  Ile Phe Ala Asn Trp  Arg Gly Phe Ser Gly  Gly Met Lys 
    2150                 2155                 2160             


Asp Met  Ser Glu Gln Met Leu  Lys Phe Gly Ala Tyr  Ile Val Asp 
    2165                 2170                 2175             


Ser Leu  Arg Leu Ser Lys Gln  Pro Val Leu Ile Tyr  Ile Pro Pro 
    2180                 2185                 2190             


Gly Ala  Glu Leu Arg Gly Gly  Ser Trp Val Val Leu  Asp Ser Ser 
    2195                 2200                 2205             


Ile Asn  Pro Leu Cys Ile Glu  Met Tyr Ala Asp Lys  Glu Ser Arg 
    2210                 2215                 2220             


Gly Gly  Val Leu Glu Pro Glu  Gly Thr Val Glu Ile  Lys Phe Arg 
    2225                 2230                 2235             


Lys Lys  Asp Leu Val Lys Thr  Ile Arg Arg Ile Asp  Pro Val Cys 
    2240                 2245                 2250             


Lys Lys  Leu Leu Glu Pro Ala  Gly Asp Thr Gln Leu  Pro Asp Lys 
    2255                 2260                 2265             


Asp Arg  Lys Glu Leu Glu Ser  Gln Leu Lys Ala Arg  Glu Asp Leu 
    2270                 2275                 2280             


Leu Leu  Pro Ile Tyr His Gln  Val Ala Val Gln Phe  Ala Asp Leu 
    2285                 2290                 2295             


His Asp  Thr Pro Gly His Met  Leu Lys Lys Gly Ile  Ile Ser Asp 
    2300                 2305                 2310             


Val Leu  Glu Trp Lys Thr Thr  Arg Thr Tyr Phe Tyr  Trp Arg Leu 
    2315                 2320                 2325             


Arg Arg  Leu Leu Leu Glu Ala  Gln Val Lys Gln Glu  Ile Leu Arg 
    2330                 2335                 2340             


Ala Ser  Pro Glu Leu Ser His  Glu His Thr Gln Ser  Met Leu Arg 
    2345                 2350                 2355             


Arg Trp  Phe Val Glu Thr Glu  Gly Ala Val Lys Ala  Tyr Leu Trp 
    2360                 2365                 2370             


Asp Ser  Asn Gln Val Val Val  Gln Trp Leu Glu Gln  His Trp Ser 
    2375                 2380                 2385             


Ala Arg  Asp Asn Leu Arg Ser  Thr Ile Arg Glu Asn  Leu Asn Tyr 
    2390                 2395                 2400             


Leu Lys  Arg Asp Ser Val Leu  Lys Thr Ile Gln Ser  Leu Val Gln 
    2405                 2410                 2415             


Glu His  Pro Glu Ala Thr Met  Gly Leu Cys Gly Tyr  Leu Ser Gln 
    2420                 2425                 2430             


His Leu  Thr Pro Ala Glu Gln  Met Gln Val Val Gln  Leu Leu Ser 
    2435                 2440                 2445             


Thr Thr  Glu Ser Pro Ala Ser  His 
    2450                 2455     


<210> 5
<211> 2387
<212> PRT
<213> Xenopus sp.

<400> 5
Met Glu Gly Asp Lys Glu Gln Leu Pro Lys Pro Pro Ile Ala Glu Ala 
1               5                   10                  15      


Glu Thr Pro Ala Glu Ser Asp Asp Asn Leu Leu Arg Thr Gln Ala Glu 
            20                  25                  30          


Gly Thr Thr Ser Gly Gln Ile Gln Asp Thr Asn Ser Gly Val Asn Ser 
        35                  40                  45              


Gly Thr Leu Pro Pro Arg Ala Ala Ser Leu Ser Lys Pro Glu Gln Lys 
    50                  55                  60                  


Gln Leu Lys Phe Ala Pro Ser Arg Gly Thr Glu Pro Val Asn Pro Lys 
65                  70                  75                  80  


Pro Arg Lys Gln Pro Leu Ser Lys Phe Ile Leu Gly Ser Ser Glu Asp 
                85                  90                  95      


Asn Ser Asp Asp Asp Glu Phe Ala Cys Gly Ser Phe Lys Thr Thr Lys 
            100                 105                 110         


Arg Asn Ser Gln Ala Ser Leu Gly Ser Gln Thr Pro Ser Leu Ser Ser 
        115                 120                 125             


Leu Pro Glu Thr Glu Ser Leu Pro Thr Met Arg Ser Ser Met Ser Gly 
    130                 135                 140                 


Leu His Leu Val Lys Lys Gly Arg Asp His Lys Lys Leu Asp Leu His 
145                 150                 155                 160 


Arg Asp Phe Thr Val Ala Ser Pro His Glu Phe Val Thr Arg Phe Gly 
                165                 170                 175     


Gly Asn Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala 
            180                 185                 190         


Ala Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ser Tyr Glu Met Phe 
        195                 200                 205             


Arg Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp 
    210                 215                 220                 


Leu Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro 
225                 230                 235                 240 


Val Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile 
                245                 250                 255     


Val Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp 
            260                 265                 270         


Gly His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Gln Lys Gln 
        275                 280                 285             


Asn Ile Ala Phe Leu Gly Pro Pro Ser Gln Ala Met Trp Ala Leu Gly 
    290                 295                 300                 


Asp Lys Ile Ala Ser Thr Ile Val Ala Gln Ala Val Gly Ile Pro Thr 
305                 310                 315                 320 


Leu Ser Trp Ser Gly Asp Gly Leu Leu Leu Glu Leu Lys Pro Asp Asp 
                325                 330                 335     


Lys Gln Gln Gln Asn Ile Ile Cys Val Pro Pro Glu Val Tyr Glu Lys 
            340                 345                 350         


Gly Cys Val Lys Asp Ala Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile 
        355                 360                 365             


Gly Tyr Pro Val Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly 
    370                 375                 380                 


Ile Arg Met Ala Glu Arg Ala Glu Asp Phe Pro Ser Leu Phe Arg Gln 
385                 390                 395                 400 


Val Gln Thr Glu Ala Pro Gly Ser Pro Ile Phe Val Met Lys Leu Ala 
                405                 410                 415     


Gln His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly 
            420                 425                 430         


His Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His 
        435                 440                 445             


Gln Lys Ile Ile Glu Glu Ala Pro Ala Thr Val Ala Thr Pro Ser Val 
    450                 455                 460                 


Phe Glu Tyr Met Glu Gln Cys Ala Val Arg Leu Ala Lys Met Val Gly 
465                 470                 475                 480 


Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Glu Asp Gly Ser 
                485                 490                 495     


Phe His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys 
            500                 505                 510         


Thr Glu Met Ile Cys Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile 
        515                 520                 525             


Ser Met Gly Val Pro Leu Tyr Arg Ile Lys Asp Ile Arg Val Leu Tyr 
    530                 535                 540                 


Gly Glu Thr Pro Trp Gly Asp Ser Pro Ile Cys Phe Glu Asn Pro Val 
545                 550                 555                 560 


Asn Ala Pro Asn Pro Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser 
                565                 570                 575     


Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu 
            580                 585                 590         


Leu Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala 
        595                 600                 605             


Ala Ala Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys 
    610                 615                 620                 


Phe Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val 
625                 630                 635                 640 


Ala Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu 
                645                 650                 655     


Tyr Leu Ile Lys Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Glu Ile 
            660                 665                 670         


Asp Thr Gly Trp Leu Asp His Leu Ile Ala Glu Lys Val Gln Ala Glu 
        675                 680                 685             


Lys Pro Asp Thr Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala 
    690                 695                 700                 


Asp Ala Leu Phe Gln Thr Cys Met Asn Glu Phe Leu His Cys Leu Glu 
705                 710                 715                 720 


Arg Gly Gln Val Leu Pro Ala Ala Ser Leu Leu Asn Ile Val Asp Val 
                725                 730                 735     


Glu Leu Ile Ser Glu Arg Val Lys Tyr Lys Leu Lys Val Ala Arg Gln 
            740                 745                 750         


Ser Leu Thr Thr Tyr Val Ile Ile Leu Asn Asn Ser His Ile Glu Ile 
        755                 760                 765             


Asp Val His Arg Leu Ser Asp Gly Gly Leu Leu Leu Ser Tyr Asp Gly 
    770                 775                 780                 


Asn Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Arg Tyr Arg Ile 
785                 790                 795                 800 


Thr Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr 
                805                 810                 815     


Val Leu Arg Ser Pro Ser Thr Gly Lys Leu Leu Gln Tyr Thr Val Glu 
            820                 825                 830         


Asp Gly Ser His Val Asn Ala Gly Glu Cys Phe Ala Glu Ile Glu Val 
        835                 840                 845             


Met Lys Met Val Met Ala Leu Thr Val Gln Glu Pro Gly Gln Ile His 
    850                 855                 860                 


Tyr Val Lys Arg Pro Gly Ala Val Leu Glu Ser Gly Cys Met Val Ala 
865                 870                 875                 880 


Gln Ile Asp Leu Asp Asp Pro Ser Lys Val Leu Gln Ala Glu Pro Tyr 
                885                 890                 895     


Thr Gly Ser Leu Leu Pro Gln Gln Thr Leu Pro Ile Ile Gly Glu Lys 
            900                 905                 910         


Leu His Gln Val Phe His Ser Val Leu Glu Asn Leu Ile Asn Val Met 
        915                 920                 925             


Asn Gly Tyr Cys Leu Pro Glu Pro Tyr Phe Thr Val Lys Ile Lys Glu 
    930                 935                 940                 


Trp Val His Lys Leu Met Lys Thr Leu Arg Asp Pro Ser Leu Pro Leu 
945                 950                 955                 960 


Leu Glu Leu Gln Glu Ile Met Thr Ser Val Ser Thr Arg Ile Pro Pro 
                965                 970                 975     


Thr Val Glu Arg Ser Ile Arg Lys Ile Met Ala Gln Tyr Ala Ser Asn 
            980                 985                 990         


Ile Thr Ser Val Leu Cys Gln Phe  Pro Ser Gln Gln Ile  Ala Ser Ile 
        995                 1000                 1005             


Leu Asp  Ser His Ala Ala Thr  Leu Gln Arg Lys Ala  Asp Arg Glu 
    1010                 1015                 1020             


Val Phe  Phe Met Asn Thr Gln  Ser Ile Val Gln Leu  Val Gln Arg 
    1025                 1030                 1035             


Tyr Arg  Ser Gly Ile Arg Gly  Tyr Met Lys Ser Val  Val Leu Asp 
    1040                 1045                 1050             


Leu Leu  Arg Arg Tyr Leu Gln  Val Glu Thr Gln Phe  Gln His Ser 
    1055                 1060                 1065             


His Tyr  Asp Lys Cys Val Ile  His Leu Arg Glu Gln  Tyr Lys Pro 
    1070                 1075                 1080             


Asp Met  Thr Pro Val Leu Glu  Cys Ile Phe Ser His  Ala Gln Val 
    1085                 1090                 1095             


Ala Lys  Lys Asn Phe Leu Val  Thr Met Leu Ile Asp  Gln Leu Cys 
    1100                 1105                 1110             


Gly Arg  Asp Pro Thr Leu Thr  Asp Glu Leu Met Ala  Ile Leu Asn 
    1115                 1120                 1125             


Glu Leu  Thr Gln Leu Ser Lys  Thr Glu His Ser Lys  Val Ala Leu 
    1130                 1135                 1140             


Arg Ala  Arg Gln Val Leu Ile  Ala Ser His Leu Pro  Ser Tyr Glu 
    1145                 1150                 1155             


Leu Arg  His Asn Gln Val Glu  Ser Ile Phe Leu Ser  Ala Ile Asp 
    1160                 1165                 1170             


Leu Tyr  Gly His Gln Phe Cys  Pro Asp Asn Leu Lys  Lys Leu Ile 
    1175                 1180                 1185             


Leu Ser  Glu Thr Ser Ile Phe  Asp Val Leu Pro Asn  Phe Phe Tyr 
    1190                 1195                 1200             


His Asn  Asn Gln Val Val Arg  Met Ala Ala Leu Glu  Val Tyr Val 
    1205                 1210                 1215             


Arg Arg  Gly Tyr Ile Ala Tyr  Glu Leu Asn Ser Leu  Gln His His 
    1220                 1225                 1230             


Gln Leu  Arg Asp Cys Thr Cys  Val Val Glu Phe Gln  Phe Met Leu 
    1235                 1240                 1245             


Pro Ser  Ser His Pro Asn Arg  Glu Ile Ser Pro Thr  Leu Ser Arg 
    1250                 1255                 1260             


Met Ser  Leu Pro Ile Ser Ala  Thr His Leu Glu Ile  Asn Arg Gln 
    1265                 1270                 1275             


Ser Ser  Glu Leu Phe Met Asp  Ser Gly Phe Ser Pro  Leu Cys Gln 
    1280                 1285                 1290             


Arg Met  Gly Val Met Val Ala  Phe Asn Lys Phe Glu  Asp Phe Thr 
    1295                 1300                 1305             


Arg Asn  Phe Asp Glu Val Ile  Ser Cys Phe Ala Asp  Pro Pro Leu 
    1310                 1315                 1320             


Asp Ser  Pro Leu Phe Ser Glu  Val Arg Ser Ser Phe  Tyr Asp Glu 
    1325                 1330                 1335             


Glu Asp  Asn Lys Asn Ile Arg  Glu Glu Pro Ile His  Ile Leu Asn 
    1340                 1345                 1350             


Val Ala  Leu Lys Ser Val Asp  Arg Met Glu Asp Glu  Glu Leu Val 
    1355                 1360                 1365             


Ser Val  Phe Arg Thr Phe Cys  Gln Ser Lys Lys Asn  Ile Leu Val 
    1370                 1375                 1380             


Asp Tyr  Gly Leu Arg Arg Ile  Thr Phe Leu Ile Ala  Gln Gln Arg 
    1385                 1390                 1395             


Glu Phe  Pro Lys Phe Phe Thr  Phe Arg Ala Arg Asp  Glu Phe Ala 
    1400                 1405                 1410             


Glu Asp  Arg Ile Tyr Arg His  Leu Glu Pro Ala Leu  Ala Phe Gln 
    1415                 1420                 1425             


Leu Glu  Leu Asn Arg Met Arg  Asn Phe Asp Leu Asn  Ala Val Pro 
    1430                 1435                 1440             


Cys Ala  Asn His Lys Met His  Leu Tyr Leu Gly Ala  Ala Lys Val 
    1445                 1450                 1455             


Ala Ala  Gly Ile Glu Val Thr  Asp Tyr Arg Phe Phe  Val Arg Ala 
    1460                 1465                 1470             


Ile Ile  Arg His Ser Asp Leu  Ile Thr Lys Glu Ala  Ser Phe Glu 
    1475                 1480                 1485             


Tyr Leu  Gln Asn Glu Gly Glu  Arg Leu Leu Leu Glu  Ala Met Asp 
    1490                 1495                 1500             


Glu Leu  Glu Val Ala Phe Asn  Asn Pro Ser Val Arg  Thr Asp Cys 
    1505                 1510                 1515             


Asn His  Ile Phe Leu Asn Phe  Val Pro Thr Val Ile  Met Asp Pro 
    1520                 1525                 1530             


Ser Lys  Ile Glu Glu Ser Val  Arg Ser Met Val Met  Arg Tyr Gly 
    1535                 1540                 1545             


Ser Arg  Leu Trp Lys Leu Arg  Val Leu Gln Ala Glu  Val Lys Ile 
    1550                 1555                 1560             


Asn Ile  Arg Leu Thr Pro Thr  Gly Lys Ala Ile Pro  Ile Arg Leu 
    1565                 1570                 1575             


Phe Leu  Thr Asn Glu Ser Gly  Tyr Tyr Leu Asp Ile  Ser Leu Tyr 
    1580                 1585                 1590             


Lys Glu  Val Thr Asp Pro Ala  Thr Gly Gln Ile Met  Phe His Ser 
    1595                 1600                 1605             


Tyr Gly  Asp Lys His Gly His  Met His Gly Met Leu  Ile Asn Thr 
    1610                 1615                 1620             


Pro Tyr  Val Thr Lys Asp Leu  Leu Gln Ser Lys Arg  Phe Gln Ala 
    1625                 1630                 1635             


Gln Ser  Leu Gly Thr Thr Tyr  Val Tyr Asp Phe Pro  Glu Met Phe 
    1640                 1645                 1650             


Arg Gln  Ala Leu Phe Lys Leu  Trp Arg Ser Gly Glu  Lys Tyr Pro 
    1655                 1660                 1665             


Lys Asp  Ile Leu Thr Tyr Thr  Glu Leu Val Leu Asp  Thr Gln Gly 
    1670                 1675                 1680             


Gln Leu  Val Gln Leu Asn Arg  Leu Pro Gly Gly Asn  Glu Val Gly 
    1685                 1690                 1695             


Met Val  Ala Phe Lys Met Asn  Leu Lys Thr Pro Glu  Tyr Pro Asn 
    1700                 1705                 1710             


Gly Arg  Glu Ile Ile Val Ile  Cys Asn Asp Ile Thr  Tyr Lys Ile 
    1715                 1720                 1725             


Gly Ser  Phe Gly Pro Gln Glu  Asp Leu Leu Phe Leu  Lys Thr Ser 
    1730                 1735                 1740             


Glu Leu  Ala Arg Lys Glu Gly  Ile Pro Arg Ile Tyr  Ile Ala Ala 
    1745                 1750                 1755             


Asn Ser  Gly Ala Arg Ile Gly  Leu Ala Glu Glu Leu  Arg His Met 
    1760                 1765                 1770             


Phe Gln  Val Ala Trp Asn Asn  Pro Ser Asp Pro Tyr  Lys Gly Phe 
    1775                 1780                 1785             


Lys Tyr  Leu Tyr Leu Arg Pro  Gln Asp Tyr Thr Lys  Ile Ser Ser 
    1790                 1795                 1800             


Met Asn  Ser Ala His Cys Glu  His Val Glu Asp Glu  Gly Glu Ser 
    1805                 1810                 1815             


Arg Tyr  Val Leu Thr Asp Ile  Ile Gly Lys Glu Glu  Gly Ile Gly 
    1820                 1825                 1830             


Val Glu  Asn Leu Arg Gly Ser  Gly Thr Ile Ala Gly  Glu Ser Ser 
    1835                 1840                 1845             


Leu Ala  Tyr Lys Glu Ile Val  Thr Ile Gly Met Val  Thr Cys Arg 
    1850                 1855                 1860             


Ala Ile  Gly Ile Gly Ala Tyr  Leu Val Arg Leu Gly  Gln Arg Val 
    1865                 1870                 1875             


Ile Gln  Val Glu Asn Ser His  Ile Ile Leu Thr Gly  Ala Ser Ala 
    1880                 1885                 1890             


Leu Asn  Lys Val Leu Gly Arg  Glu Val Tyr Thr Ser  Asn Asn Gln 
    1895                 1900                 1905             


Leu Gly  Gly Val Gln Ile Met  Cys Asn Asn Gly Val  Ser His Thr 
    1910                 1915                 1920             


Met Val  Pro Asp Asp Phe Glu  Gly Val Tyr Thr Ile  Leu Gln Trp 
    1925                 1930                 1935             


Leu Ser  Tyr Met Pro Lys Asp  Asn Gln Ser Pro Val  Pro Val Ile 
    1940                 1945                 1950             


Pro Pro  Met Asp Pro Val Asp  Arg Gln Ile Glu Phe  Met Pro Thr 
    1955                 1960                 1965             


Lys Ala  Pro Tyr Asp Pro Arg  Trp Met Leu Ala Gly  Arg Pro His 
    1970                 1975                 1980             


Pro Thr  Ile Lys Gly Glu Trp  Gln Arg Gly Phe Phe  Asp His Gly 
    1985                 1990                 1995             


Ser Phe  Met Glu Ile Met Gln  Arg Trp Ala Gln Thr  Val Val Val 
    2000                 2005                 2010             


Gly Arg  Ala Arg Leu Gly Gly  Ile Pro Val Gly Val  Ile Ala Val 
    2015                 2020                 2025             


Glu Thr  Arg Ser Val Glu Met  Ala Val Pro Ala Asp  Pro Ala Asn 
    2030                 2035                 2040             


Leu Asp  Ser Glu Ala Lys Ile  Ile Gln Gln Ala Gly  Gln Val Trp 
    2045                 2050                 2055             


Phe Pro  Asp Ser Ala Phe Lys  Thr Ala Gln Ala Ile  Lys Asp Phe 
    2060                 2065                 2070             


Asn Arg  Glu Arg Leu Pro Leu  Leu Ile Phe Ala Asn  Trp Arg Gly 
    2075                 2080                 2085             


Phe Ser  Gly Gly Met Lys Asp  Met Tyr Asp Gln Val  Leu Lys Phe 
    2090                 2095                 2100             


Gly Ala  Tyr Ile Val Asp Ser  Leu Arg Glu Phe Lys  Gln Pro Val 
    2105                 2110                 2115             


Leu Val  Tyr Ile Pro Pro Tyr  Ala Glu Leu Arg Gly  Gly Ser Trp 
    2120                 2125                 2130             


Val Val  Ile Asp Pro Thr Ile  Asn Pro Leu Tyr Met  Glu Leu Tyr 
    2135                 2140                 2145             


Ala Asp  Lys Asp Ser Arg Gly  Gly Val Leu Glu Pro  Glu Gly Thr 
    2150                 2155                 2160             


Val Glu  Ile Arg Phe Arg Lys  Lys Asp Leu Ile Lys  Thr Met Arg 
    2165                 2170                 2175             


Arg Ile  Asp Pro Val Tyr Thr  Gln Ile Val Glu Gln  Leu Gly Ser 
    2180                 2185                 2190             


Pro Glu  Leu Thr Glu Gly Glu  Arg Lys Glu Leu Glu  Lys Lys Leu 
    2195                 2200                 2205             


Arg Leu  Arg Glu Glu Gln Leu  Leu Pro Ile Tyr His  Gln Val Ala 
    2210                 2215                 2220             


Val Arg  Phe Ala Asp Leu His  Asp Thr Pro Gly Arg  Met Gln Glu 
    2225                 2230                 2235             


Lys Gly  Val Ile Thr Asp Ile  Leu Glu Trp Lys Asp  Ala Arg Ser 
    2240                 2245                 2250             


Phe Leu  Tyr Trp Arg Leu Arg  Arg Leu Leu Leu Glu  Glu Met Val 
    2255                 2260                 2265             


Lys Ser  Glu Ile Leu His Ala  Asn Ser Glu Leu Ser  Asp Ile His 
    2270                 2275                 2280             


Ile Gln  Ser Met Leu Arg Arg  Trp Phe Met Glu Thr  Glu Gly Ala 
    2285                 2290                 2295             


Val Lys  Thr Tyr Leu Trp Asp  Asn Asn Gln Val Val  Val Glu Trp 
    2300                 2305                 2310             


Leu Glu  Lys His Leu Gln Glu  Glu Asp Glu Ala Arg  Ser Ala Ile 
    2315                 2320                 2325             


Arg Glu  Asn Ile Lys Tyr Leu  Lys Lys Asp Tyr Ala  Leu Lys His 
    2330                 2335                 2340             


Ile Arg  Gly Leu Val Gln Ala  Asn Pro Glu Val Ala  Met Asp Cys 
    2345                 2350                 2355             


Ile Val  His Met Thr Gln His  Ile Thr Pro Ala Gln  Arg Ala Gln 
    2360                 2365                 2370             


Leu Thr  Arg Leu Leu Ser Thr  Met Asp Asn Thr Pro  Pro Ser 
    2375                 2380                 2385         


<210> 6
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ACC2 peptide

<400> 6
Gly Phe Pro Leu Met Ile Lys Ser 
1               5               


<210> 7
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ACC2 peptide

<400> 7
Gly Phe Pro Val Met Ile Lys Ser 
1               5               


<210> 8
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ACC2 peptide

<400> 8
Gly Phe Pro Leu Met Ile Lys Ser Ala Ser Glu Gly Gly Gly Gly Lys 
1               5                   10                  15      


<210> 9
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ACC2 peptide

<400> 9
Gly Phe Pro Val Met Ile Lys Ser Ala Ser Glu Gly Gly Gly Gly Lys 
1               5                   10                  15      


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 11
His His His His His His 
1               5       


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 13
<211> 720
<212> DNA
<213> Homo sapiens

<400> 13
atgcccctgg gacacatcat gaggctggac ctggagaaaa ttgccctgga gtacatcgtg       60

ccctgtctgc acgaggtggg cttctgctac ctggacaact tcctgggcga ggtggtgggc      120

gactgcgtcc tggagcgcgt caagcagctg cactgcaccg gggccctgcg ggacggccag      180

ctggcggggc cgcgcgccgg cgtctccaag cgacacctgc ggggcgacca gatcacgtgg      240

atcgggggca acgaggaggg ctgcgaggcc atcagcttcc tcctgtccct catcgacagg      300

ctggtcctct actgcgggag ccggctgggc aaatactacg tcaaggagag gtctaaggca      360

atggtggctt gctatccggg aaatggaaca ggttatgttc gccacgtgga caaccccaac      420

ggtgatggtc gctgcatcac ctgcatctac tatctgaaca agaattggga tgccaagcta      480

catggtggga tcctgcggat atttccagag gggaaatcat tcatagcaga tgtggagccc      540

atttttgaca gactcctgtt cttctggtca gatcgtagga acccacacga agtgcagccc      600

tcttacgcaa ccagatatgc tatgactgtc tggtactttg atgctgaaga aagggcagaa      660

gccaaaaaga aattcaggaa tttaactagg aaaactgaat ctgccctcac tgaagactga      720


<210> 14
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Arg Ile Thr Ser Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly 
1               5                   10                  15      


Thr Val Gln Glu Leu Asn Phe Arg Ser 
            20                  25  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Arg Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe 
1               5                   10                  15  


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Lys Glu Ala Ser Phe Glu Tyr Leu Gln Asn Glu Gly Glu Arg Leu 
1               5                   10                  15  


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Arg Ala Ile Gly Ile Gly Ala Tyr Leu Val Arg Leu 
1               5                   10          


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Lys Asp Met Tyr Asp Gln Val Leu Lys Phe 
1               5                   10  


<210> 19
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
agaagctttg atcatcaatg caaaaccaat tctttctgct gc                          42


<210> 20
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
gcagcagaaa gaattggttt tgcattgatg atcaaagctt ct                          42


<210> 21
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ccgcctgcac ggcgattctc ttggc                                             25


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gccaagagaa tcgccgtgca ggcgg                                             25


<210> 23
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gtaggctgag tctgcgaacc acacctgtc                                         29


<210> 24
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gacaggtgtg gttcgcagac tcagcctac                                         29


<210> 25
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
ggcagcagaa agaattggtt ttggattgat gatcaaagct tctga                       45


<210> 26
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
tcagaagctt tgatcatcaa tccaaaacca attctttctg ctgcc                       45


<210> 27
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
cagatcgtag gaacccagcc gaagtgcagc cct                                    33


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
agggctgcac ttcggctggg ttcctacgat ctg                                    33


<210> 29
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gccctcttac gcaaccaaat atgctatgac tgtct                                  35


<210> 30
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
agacagtcat agcatatttg gttgcgtaag agggc                                  35


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cacctgcatc tactatctga a                                                 21


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide 

<400> 32
gtggcttgct atccgggaaa t                                                 21


<210> 33
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
acgggctcgg gtacgtaag                                                    19


<210> 34
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
cccagttctg attcaggtaa tagataca                                          28


<210> 35
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gacctgatac gccactgtaa cg                                                22


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
cccggataac aagcaaccat                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
atactacgtc aaggagaggt                                                   20


<210> 38
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
tcagcatcaa agtaccaga                                                    19


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
agatgagtat gcctgccgtg tgaa                                              24


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
tgctgcttac atgtctcgat ccca                                              24


<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
atcccgtacc ttcttctact g                                                 21


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
cccaaacata agccttcact g                                                 21


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
ctctgaccat gttcgttctc                                                   20


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
atcttcatca cctccatctc                                                   20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
gattttgctg tcggtcttgg                                                   20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ctcttgctgc ctgaatgtga                                                   20


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
attcccaccg cggaaggtgc                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
gcagcctggg ggcagtcttg                                                   20


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
tcattgtgga agcagatacc c                                                 21


<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
cagctccgtc accaattaaa ac                                                22


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
tgtggaagga gtttcgcag                                                    19


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
gggatatgct ggtgttctca g                                                 21


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
ccacttgctg tgccaaatgg a                                                 21


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
gaaggacttt accttccagg a                                                 21


<210> 55
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
gattgtccgt aacattctca tcga                                              24


<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
tgtcttgagc cgctctgaga t                                                 21


<210> 57
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
accctgctgg gtttatggat gtca                                              24


<210> 58
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
tacgatgaac agcaaagcga ccct                                              24


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
cagaccgcag gaatccacat                                                   20


<210> 60
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
ttcagcatcg aagtaccaga cagt                                              24


<210> 61
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Glu Arg Ile Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Ala Gly Gln Val Trp Phe Pro Asp Ser Ala Tyr Lys Thr Ala Gln 
1               5                   10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Ala Arg Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu 
1               5                   10                  15  


<210> 64
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly His Ala Ser 
1               5                   10                  15      


Glu Asn Pro Lys Leu 
            20      


<210> 65
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly Phe Pro 
1               5                   10                  15      


Leu Met Ile Lys Ala 
            20      


<210> 66
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Lys Ile Ile Gln Gln Ala Gly Gln Val Trp Phe Pro Asp Ser Ala Tyr 
1               5                   10                  15      


Lys Thr 
        


<210> 67
<211> 18
<212> PRT
<213> Homo sapiens

<400> 67
Glu Arg Ile Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 68
<211> 18
<212> PRT
<213> Rattus sp.

<400> 68
Glu Lys Val Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 69
<211> 18
<212> PRT
<213> Mus sp.

<400> 69
Glu Lys Ile Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 70
<211> 18
<212> PRT
<213> Caenorhabditis elegans

<400> 70
His Asn Ile Gly Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 71
<211> 18
<212> PRT
<213> Drosophila sp.

<400> 71
Asn Lys Ile Gly Phe Pro Val Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 72
<211> 18
<212> PRT
<213> Saccharomyces cerevisiae

<400> 72
Lys Arg Ile Gly Phe Pro Val Met Ile Lys Ala Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210> 73
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly Phe Pro Leu 
1               5                   10                  15      


Met Ile Lys 
            


